ORIGINAL_ARTICLE
An in-depth study of specific pathway associated to abnormal reproductive system: A meta-analysis in a specific Caucasian ethnicity
Human methylenetetrahydrofolate reductase (MTHFR) gene plays a vital role in folate metabolism. This gene is located on chromosome 1 and has 12 exons. Many single nucleotide polymorphisms are found in MTHFR gene, in which the C677T variation is one of the key polymorphism. In this literature review, four experimental studies investigating the correlation of the abovementioned polymorphism with male infertility in Iranian population were enrolled (a specific Caucasian ethnicity). To obtain more comprehensive outcomes, a meta-analysis was made by data extraction from four published papers. Eligible studies were found through a comprehensive search using appropriate electronic databases and were analyzed by Metagenyo online software. Finally, significant associations between C677T gene polymorphism and male infertility in TT vs. CC, CT vs. CC, TT+TC vs. CC, and TT vs. TC+CC genetic models were found in Iranian population with no publication bias. MTHFR gene polymorphisms could be associated with infertility in men. Thus, determination of a polymorphism genotype in this gene could be useful for infertile individuals screening.
http://www.cajmpsi.com/article_126762_bcaa1f1b9eacf4cfb6132e1a1d3cd7ec.pdf
2021-02-01
1
7
10.22034/CAJMPSI.2021.01.01
Male reproductive system
MTHFR gene
Polymorphism
Meta-analysis
Mohsen
Mohammadi
mohsenmohammadi.tums@gmail.com
1
Department of Educational Medicine, Tehran University of Medical Sciences, Tehran, Iran
LEAD_AUTHOR
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ORIGINAL_ARTICLE
Quantitative analysis of p53 substitution mutation and breast cancer; An informative study in Iranian population
Genetic factors including genetic variations in important genes may influence breast cancer susceptibility. One of important gene variations is p53 codon 72 which might impact risk of breast cancer. There are three case-control genetic association studies regard to the relation of this polymorphism with breast cancer risk in Iranian females, but the outcomes are indecisive. So, a meta-analysis was made in Iranian population in this regard. The eligible studies were found using search in appropriate databases. So, the extracted information from comprised studies was examined by Open Meta analyst program. The analyzed data displayed that there is no substantial correlation of p53 codon 72 substitution with risk of breast cancer in CC vs. GG (OR= 0.844, 95%CI= 0.244-2.916, p= 0.789) and GC vs. GG (OR= 1.215, 95%CI= 0.880-1.676, p= 0.237) models in Iran. Regarding to the outcomes, the aforementioned polymorphism is not a molecular risk factor for breast cancer in Iranian population.
http://www.cajmpsi.com/article_126763_98755dd84f3ad67cf12bc428e31d6be9.pdf
2021-02-01
8
14
10.22034/CAJMPSI.2021.01.02
breast cancer
p53 gene
Genetic polymorphism
Meta-analysis
Mojtaba
Sabernezhad
sabernezhadmojtabaa@gmail.com
1
Department of Biology, Faculty of Basic Sciences, University of Isfahan, Isfahan, Iran
LEAD_AUTHOR
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ORIGINAL_ARTICLE
Study of A1298C variation in MTHFR gene as a molecular risk factor for male infertility in Iran
Methylenetetrahydrofolate reductase is an important enzyme in folate metabolism pathway. Some studies investigated the correlation of a common gene variation (A1298C) with male infertility in a specific Caucasian population (Iran), but the outcomes are controversial. Thus, the current study employed a meta-analysis to determine the association of mentioned variation with male infertility in Iranian population. PubMed, Google Scholar, EMBASE, SID, and Magiran databases were searched to recognize eligible publications. The odds ratios (ORs) was used with corresponding 95% confidence intervals (95% CIs) to assess the strength of genetic association analysis. The data were analyzed through Metagenyo software. Generally, three qualified papers were found and included in the quantitative synthesis (meta-analysis). The obtained data displayed that the variation is not correlated with male infertility in co-dominant genetic models. Also, the results showed no significant heterogeneities among eligible included studies. Moreover, publication bias was not detected in the current analysis. A1298C polymorphism in MTHFR gene is not correlated with male infertility in Iranian population, and it could not be considered as a risk factor for male infertility.
http://www.cajmpsi.com/article_126764_87b53c50e01dc111e5c931d55ddabbd8.pdf
2021-02-01
15
21
10.22034/CAJMPSI.2021.01.03
Idiopathic Male Infertility
MTHFR
Genetic polymorphism
Quantitative synthesis
Omid
Hassanpour
ohassanpoor69@gmail.com
1
Department of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
LEAD_AUTHOR
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ORIGINAL_ARTICLE
Role of ESR1 PvuII T/C variant in female reproductive process: A review
Estrogen hormone is involved in the process of reproduction by banding to estrogen receptors (ERs). The findings of previous studies showed the association of a common variant, PvuII T/C (rs 2234693), in ESR1 gene with different aspects of reproductive process in women. Thus, the present review focused on effect of this genetic variant on reproductive process in females. The results demonstrated that the variant of ESR1 PvuII T/C (rs 2234693) could be associated with numbers of collected oocyte, maturation and embryo quality, spontaneous abortions, pregnancy rate following in vitro manipulations, preeclampsia, predisposition to endometriosis and infertility. In conclusion, the present study suggested that ESR1 PvuII T/C (rs 2234693) variant might play an important role in potential of females fertility given to the various ethnic backgrounds. Nonetheless, further studies are required in order to determine the more exact role of this variant in the infertility of women.
http://www.cajmpsi.com/article_126765_623300e56879514bb9a013ac71f356a2.pdf
2021-02-01
22
27
10.22034/CAJMPSI.2021.01.04
Estrogen Receptor
ESR1 PvuII T/C Variant
Reproduction
Infertility
Rezvan
Asgari
r.asgari33@gmail.com
1
Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
LEAD_AUTHOR
Brugo-Olmedo S, Chillik C, Kopelman S. Definition and causes of infertility. Reprod Biomed online 2001; 2(1): 173-185.
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ORIGINAL_ARTICLE
Investigation of the effect of pd1.1, pd1.5, and pd1.9 mutations on pd1 gene function with a system biology approach
Programmed cell death 1 (pd1) is an immune-inhibitory receptor that is expressed in activated T cells. This gene may play a role in inhibition of actual anti- microbial and anti-tumor immunity. In human, this gene is located on the long arm of chromosome 2. This gene has many variations that three of which are more common. This study was aimed to investigate the influence of pd1.1, pd1.5, and pd1.9 variations on function of pd1gene based on a bioinformatics approach. In this study, the EPD and PROMO webserver was used to evaluate the pd1.1 variation as a promoter mutation. It has been detected in the promoter region by EPD, while the transcription factor arrangement was evaluated by the PROMO server. But, some bioinformatics tools such as ProtScale – ExPASy and Ramachandran plot assay web servers were used to evaluate the effects of codding polymorphisms. Obtained data from EPD showed that the promoter of pd1 contains 60 nucleotides. Evaluation of upstream of pd1 revealed that the number of transcription factors could alter the pd1.1 variation. With regard to the pd1.5 polymorphisms, the result showed that it is considered as a synonymous variation, but the pd1.9 was known as a nonsynonymous mutation. Thus, the pd1.9 could alter the hydrophobicity and Ramachandran plots of PD1. The pd1.5 mutation may impact the expression of the pd1gene because it changes the transcription factor arrangement on the upstream of pd1. Also, the pd1.9 substitution could alter the hydrophobicity and Ramachandran plots of protein.
http://www.cajmpsi.com/article_126766_03aadf4adc36c467dc4d745fbf9a9a9a.pdf
2021-02-01
28
34
10.22034/CAJMPSI.2021.01.05
PD1 protein
genetic mutations
Bioinformatics
promoter region
Gene function
Mohammad Reza
Roshandel
mr.roshandel@yahoo.com
1
Department of Urology, Icahn School of Medicine, Mount Sinai Hospitals, NY, USA.
AUTHOR
Hawri
Mustafa Bakr
h.m.bakr@gmail.com
2
Department of Basic Science, College of Medicine, Hawler Medical University, Erbil, Iraq.
AUTHOR
Ramin
Lak
raminlak98@yahoo.com
3
Pars Advanced and Minimally Invasive Medical Manners Research Center, Pars Hospital, Iran.
AUTHOR
Ruqaya
Muhammed Ghareeb Taher Al Barzinji
ruqaya.mgtbarzinji@hotmail.com
4
Department of Basic Science, College of Medicine, Hawler Medical University, Erbil, Iraq.
AUTHOR
Khonaw
Kader Salh
kk.salh1995@gmail.com
5
Department of Basic Science, College of Medicine, Hawler Medical University, Erbil, Iraq.
AUTHOR
Kharman
Saeed Ibrahim
ks.brahim@yahoo.com
6
Department of Basic Science, College of Medicine, Hawler Medical University, Erbil, Iraq.
AUTHOR
Feyan
Mirdan Abdullah
feyan.mirdan@hmu.edu.krd
7
Department of Basic Science, College of Medicine, Hawler Medical University, Erbil, Iraq.
LEAD_AUTHOR
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ORIGINAL_ARTICLE
The crucial role of estrogen/androgen hormones and their receptors in male infertility risk
Steroid hormones, including androgen and estrogen, regulate gene transcription in several tissues, especially in reproductive systems. It has been shown that these hormones are vital for regulation of spermatozoa released from the epithelial cells of seminiferous tubes, a procedure which is characterized by endocytosis and broad regeneration of actin filaments. A subgroup of sterile men displayed decreased levels of testosterone and elevated concentrations of estrogen. Nevertheless, it is undecided how increased levels of estrogen could decrease male fertility potential. Though the molecular origin for estrogen-induced decreased male fertility levels remains vague, estrogen receptors (ERs) have an essential role in facilitating this procedure. In addition, the androgen hormone plays an important role in male reproductive system. They act through their receptors, the androgen receptor (AR). It has been reported that AR mutations could result in idiopathic male infertility. In this review, the role of estrogen and androgen hormones and their receptors in male infertility were discussed.
http://www.cajmpsi.com/article_126833_894816a6e2c78ad4b63534d96ad45f80.pdf
2021-02-01
35
43
10.22034/CAJMPSI.2021.01.06
Male infertility
estrogen
Androgen
hormone receptors
Paola
A. Rivera-Diaz
pa.riveradiaz@yahoo.com
1
Faculty of Health, Institute of Biomedical Research, Santiago de Cali University, Cali, Colombia
AUTHOR
Claudia
Patricia Ortiz
claudia.po@gmail.com
2
Occupational Health and Safety Administration Program (Research Seedbed), Minuto de Dios University Corporation (UNIMINUTO), Huila, Colombia
AUTHOR
Daniel
Ricardo Delgado
danielr.delgado@campusucc.edu.co
3
Department of Engineering, Industrial Engineering Program, GRIAUCC Research Group, University Colombia, Huila, Colombia
LEAD_AUTHOR
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