An in-depth study of specific pathway linked to abnormal reproductive system: A meta-analysis in a specific Caucasian ethnicity

Document Type : Research Paper

Author

Department of Educational Medicine, Tehran University of Medical Sciences, Tehran, Iran

Abstract

The human methylene tetrahydrofolate reductase (MTHFR) gene plays a vital role in folate metabolism. This gene is located on chromosome 1 and has 12 exons. Many single nucleotide polymorphisms are found in the MTHFR gene. One of the key polymorphisms in this gene is C677T variation. In a literature review four experimental works investigating the correlation of the mentioned polymorphism with male infertility in Iranian population were enrolled (a specific Caucasian ethnicity). To obtain more comprehensive outcomes, we made a meta-analysis by pooling the data from four existed papers. Eligible studies were found the by a search in appropriate electronic databases. The data from four studies were extracted and so analyzed by Metagenyo online software. The results showed that there are significant associations between C677T gene polymorphism and male infertility in TT vs. CC, CT vs. CC, TT+TC vs. CC, and TT vs. TC+CC genetic models within Iranian population without any publication bias. The results showed that polymorphisms in the MTHFR gene could be associated with infertility in men. Therefore, determining the genotype of a polymorphism in this gene will be very useful for screening infertile people.

Graphical Abstract

An in-depth study of specific pathway linked to abnormal reproductive system: A meta-analysis in a specific Caucasian ethnicity

Keywords


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