Quantitative analysis of the p53 substitution mutation and breast cancer: An informative study in Iranian population

Document Type : Research Paper

Author

Department of Biology, Faculty of Basic Sciences, University of Isfahan, Isfahan, Iran

Abstract

Genetic factors including genetic variations in important genes may influence breast cancer susceptibility. One of important gene variations is p53 codon 72 which might impact risk of breast cancer. There are three case-control genetic association studies regard to the relation of this polymorphism with breast cancer risk in Iranian females, but the outcomes are indecisive. So, a meta-analysis was made in Iranian population in this regard. The eligible studies were found using search in appropriate databases. So, the extracted information from comprised studies was examined by Open Meta analyst program. The analyzed data displayed that there is no substantial correlation of p53 codon 72 substitution with risk of breast cancer in CC vs. GG (OR= 0.844, 95%CI= 0.244-2.916, p= 0.789) and GC vs. GG (OR= 1.215, 95%CI= 0.880-1.676, p= 0.237) models in Iran. Regarding to the outcomes, the aforementioned polymorphism is not a molecular risk factor for breast cancer in Iranian population.

Graphical Abstract

Quantitative analysis of the p53 substitution mutation and breast cancer: An informative study in Iranian population

Highlights

  • Genetic variations in tumor suppressor genes such as p53 protein could impact breast cancer.
  • One of main gene variations is p53 codon 72 which could alter the risk of breast tumors.
  • The codon 73 in p53 is not a risk factor for breast cancer in Iranian population.

Keywords

Main Subjects


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