The study of A1298C variation in MTHFR gene as a molecular risk factor for male infertility in Iran

Document Type : Research Paper

Author

Department of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Abstract

Methylenetetrahydrofolate reductase is an important enzyme in folate metabolism pathway. There are some study investigating the correlation of a common gene variation (A1298C) with male infertility in a specific Caucasian population (Iran) but the outcomes are controversial. So, the current study employed a meta-analysis to determine the association of mentioned variation with male infertility in the above-mentioned population. PubMed, Google Scholar, EMBASE, SID and Magiran databases were searched to recognize eligible publications. We used odds ratios (ORs) with corresponding 95% confidence intervals (95% CIs) to assess the strength of genetic association analysis. The data were analyzed through Metagenyo software. In overall, three qualified papers were found and included in the quantitative synthesis (meta-analysis). Our data displayed that the variation is not correlated with male infertility in co-dominant genetic models. Also, we find no significant heterogeneities among eligible included studies. Moreover, publication bias did not observe in our analysis. This meta-analysis proposes that A1298C polymorphism in MTHFR gene is not correlated with male infertility in Iranian population and it could not be counted as a risk factor for male infertility.

Graphical Abstract

The study of A1298C variation in MTHFR gene as a molecular risk factor for male infertility in Iran

Highlights

  • Methylene tetrahydrofolate reductase molecule could be a key enzyme in cellular procedure.
  • The A1298C genetic variation is an exonic SNP in MTHFR sequence.
  • The A1298C genetic polymorphism is not correlated with male infertility risk.

Keywords

Main Subjects


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