The role of ESR1 PvuII T/C variant in the female reproductive process: A review

Document Type : Review Paper

Author

Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

Abstract

Estrogen hormone is involved in the process of reproduction by banding to estrogen receptors (ERs). The findings of previous studies showed the association of a common variant, PvuII T/C (rs 2234693), in the gene of ESR1 with the different aspects of the reproductive process in women. Thus, the present review focuses on effect of this genetic variant on the process of reproductive in females. The results demonstrates that the variant of ESR1 PvuII T/C (rs 2234693) can associated with  numbers of collected oocyte, the maturation and embryo quality, spontaneous abortions, pregnancy rate following in vitro, preeclampsia, predisposition to endometriosis and infertility. In conclusion, the present study suggested that ESR1 PvuII T/C (rs 2234693) variant might play the important role in the potential fertility of females given to the various ethnic backgrounds. Nonetheless, the further studies are required in order to determine the more exact role of this variant in the infertility of women.

Graphical Abstract

The role of ESR1 PvuII T/C variant in the female reproductive process: A review

Highlights

  • Estrogen hormone via its receptors (ERs) plays the important role in the reproductive functions.
  • PvuII T/C (rs 2234693) is a common genetic variant in the ESR1 gene.
  • PvuII T/C (rs 2234693) variant is related to the female reproductive functions.
  • This genetic variant might has the significant role in the potential fertility of women.

Keywords

Main Subjects


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