The crucial role of estrogen/androgen hormones and their receptors in male infertility risk

Document Type : Review Paper


1 Faculty of Health, Institute of Biomedical Research, Santiago de Cali University, Cali, Colombia

2 Occupational Health and Safety Administration Program (Research Seedbed), Minuto de Dios University Corporation (UNIMINUTO), Huila, Colombia

3 Department of Engineering, Industrial Engineering Program, GRIAUCC Research Group, University Colombia, Huila, Colombia


Steroid hormones including androgen and estrogen, regulate gene transcription in several tissues, especially in reproductive systems. It has been shown that the two mentioned hormones are vital for the regulation of spermatozoa release from the epithelium cells in seminiferous tubes, a procedure is characterized by endocytosis and broad regeneration of actin filaments. A subgroup of sterile men displays decreased testosterone and elevated concentration of estrogen, nevertheless, it is undecided how increased estrogen promotes worsening of male fertility. Though the molecular origin for estrogen-induced worsening of male fertility remains vague, estrogen receptors (ERs) have an essential role in facilitating this procedure. In addition, the androgen hormone plays an important role in the male reproductive system. They action through their receptors, androgen receptor (AR). It has been reported that AR mutations could result in idiopathic male infertility. In this review, the role of estrogen and androgen hormones and their receptors in male infertility, have been discussed.

Graphical Abstract

The crucial role of estrogen/androgen hormones and their receptors in male infertility risk


  • Male infertility as a universal problem could be affected by steroid hormones.
  • Androgen and estrogen as steroid hormones control gene expression in reproductive organs.
  • Variation in esterogen and progestron receptors could alter the risk of male infertility.


Main Subjects

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