@article { author = {Aziziaram, Zahra}, title = {C3953T genetic variation in interleukin 1β and idiopathic male infertility: a systematic review and meta-analysis}, journal = {Central Asian Journal of Medical and Pharmaceutical Sciences Innovation}, volume = {1}, number = {6}, pages = {242-249}, year = {2021}, publisher = {Central Asian Scientific Press (CAS Press)}, issn = {2783-0993}, eissn = {2783-0993}, doi = {10.22034/CAJMPSI.2021.06.01}, abstract = {According to the World Health Organization, infertility means that a couple will not have children after 12 months of unprotected sex. Half of all cases of infertility are due to male factors. Environmental and genetic factors play a role in idiopathic infertility in men. Genetic polymorphisms in cytokine family genes may be an important risk factor for male infertility. This study aimed to investigate the association of C3953T polymorphism in the interleukin-1-beta gene with male infertility through a meta-analysis approach. For this study, an electronic search was conducted in reputable databases such as PubMed, Google Scholar, and Science Direct. Finally, three eligible studies were included in our meta-analysis. The results of the meta-analysis showed that C3953T polymorphism was associated with male infertility in allelic model (OR= 1.2143, 95% CI= 1.0057; 1.4662, p= 0.0433) and homozygous codominant model (OR= 3.0292, 95% CI= 1.5681; 5.8519, p= 0.00097). Another study also showed that there was no publication bias in our study and a sensitivity analysis showed that the exclusion of one study could not have a significant effect on the pooled ORs. Based on these results, the C3953T polymorphism may be a genetic risk factor for idiopathic infertility in men. However, due to the limited number of studies in this meta-analysis, further studies with higher sample sizes and different races are needed to obtain more accurate results.}, keywords = {Male infertility,Interleukin 1β,C3953T polymorphism,Meta-analysis}, url = {http://www.cajmpsi.com/article_141979.html}, eprint = {http://www.cajmpsi.com/article_141979_b5fa2cb3c8257458a64c56af1aabdbf0.pdf} } @article { author = {Khafaei, Mostafa}, title = {MicroRNAs as precise diagnostic biomarkers: A review}, journal = {Central Asian Journal of Medical and Pharmaceutical Sciences Innovation}, volume = {1}, number = {6}, pages = {250-257}, year = {2021}, publisher = {Central Asian Scientific Press (CAS Press)}, issn = {2783-0993}, eissn = {2783-0993}, doi = {10.22034/CAJMPSI.2021.06.02}, abstract = {miRNAs (also known as endogenous noncoding RNAs, or "ncRNAs") are a family of endogenous ncRNAs that are small (about 22 nucleotides in length). Too far, about 2,500 distinct microRNAs have been reported in various publications and new interest in miRNA biological function has arisen due to the recent advancement in molecular biology, As a result, it's unsurprising that abnormal miRNA expression plays a role in the pathogenesis of a variety of illnesses, including cardiovascular disease, neurodegenerative disease, and cancer. Current needs are not being satisfied by conventional miRNA detection techniques. In contrast, immunoassay techniques, and next-generation sequencing (NGS) have been extensively used to detect miRNA with great sensitivity. These novel methods have advanced the functional study and clinical diagnostics of miRNAs. In this paper, we highlight the latest advancements in miRNA detection methods and their possible future uses. It will guide follow-up methods that are very sensitive and specific as well as pertinent to disease diagnosis and treatment.}, keywords = {MicroRNAs,RNA hybridizes,Locked nucleic acid (LNA),pirRNA,siRNAs}, url = {http://www.cajmpsi.com/article_142019.html}, eprint = {http://www.cajmpsi.com/article_142019_ca9742c770addc3d785f80374bceda6d.pdf} } @article { author = {Kahrarian, Zahra and Vaziri, Sivash and Mojarrab, Mehdi}, title = {Evaluation of antimicrobial activity of essential oil of Pistacia khinjuk in Iran}, journal = {Central Asian Journal of Medical and Pharmaceutical Sciences Innovation}, volume = {1}, number = {6}, pages = {258-263}, year = {2021}, publisher = {Central Asian Scientific Press (CAS Press)}, issn = {2783-0993}, eissn = {2783-0993}, doi = {10.22034/CAJMPSI.2021.06.03}, abstract = {Today, with increasing prevalence antibiotic resistance monitoring the health and quality of food has become complicated and difficult. Therefore, essential oils of medicinal plants is significant and the  investigation on the composition of essential oil  of Pistacia khinjuk is important. Due to antimicrobial effects and food preservative of various species of this plant. In this study aim was to Survey the antimicrobial activity of the essential oil of Pistacia khinjuk in Iran. This study data collection by articles in internal databases such as, Irandoc, SID and external databases including Science Direct, Scopus, PubMed, Elsevier, Google Scholar. The comparison of the analysis of the essential oil of this plant related to the geographical diversity in Iran. The major compounds of essential oil from the  P. khinjuk are α-pinene, β-pinene, Myrcene, beta-caryophyllene, Germacrene B and Spathulenol. The extracts showed antimicrobial activity against bacteria and fungi. The essential oil of the different leaves extracts of P. khinjuk (chloroform, ethyl acetate, ethyl alcohol, diethyl ether) like other species of Pistacia khinjuk show antibacterial and antifungal activities.}, keywords = {Antioxidant,Pistacia khinjuk,Plant medicine,Essential oil,Antimicrobial}, url = {http://www.cajmpsi.com/article_142162.html}, eprint = {http://www.cajmpsi.com/article_142162_64e9b1152987af035ed8961c72e403cf.pdf} } @article { author = {Kamyab Hesari, Kambiz and Molkizadeh, Melika and Bokharaei, Amirkian and Mohajertehran, Farnaz}, title = {The role of molecular factors in gestational hypertension and the pathogenesis of preeclampsia}, journal = {Central Asian Journal of Medical and Pharmaceutical Sciences Innovation}, volume = {1}, number = {6}, pages = {264-271}, year = {2021}, publisher = {Central Asian Scientific Press (CAS Press)}, issn = {2783-0993}, eissn = {2783-0993}, doi = {10.22034/CAJMPSI.2021.06.04}, abstract = {Preeclampsia (PE) is classified as a systemic condition that generally develops with high blood pressure and protein excretion in pregnant women after 20 weeks. This condition is characterised by inadequate placental blood flow and damages several organs. The illness is a complicated ailment that starts with an aberrant trophoblast invasion of the uterine decidua, endothelial dysfunction, and platelet aggregation, finally leading to a faulty placenta. Defective placenta causes difficulties such as hypoxia, oxidative stress, stimulation of the mother's immune system, and some other situations. Although the specific origin of this illness has not yet been discovered, various cellular signalling pathways may be implicated in its development. One of the molecules that may be implicated in preeclampsia is the sFlt-1 molecule. This protein has an inhibitory influence on vascularization of the placenta by lowering signalling VEGF, which leads to apoptosis of foetal vascular and disrupted placenta and exchange of nutrients, which finally leads to foetal growth limitation and preeclampsia. The renin-angiotensin-aldosterone pathway, inflammatory cytokines, and the Nrf2/HO-1 pathway are also implicated in the pathophysiology of this condition. The biogenesis route of microRNAs involved in controlling gene expression might be regarded as extra variables implicated in preeclampsia. The goal of this work was to elucidate the molecular components involved in the pathophysiology of preeclampsia.}, keywords = {preeclampsia,blood pressure,risk factor,cytokine,MicroRNA}, url = {http://www.cajmpsi.com/article_142282.html}, eprint = {http://www.cajmpsi.com/article_142282_783fef863f86438536c5e93718bb1127.pdf} }