ORIGINAL_ARTICLE
Association of glutathione S-transferase M1 null mutation with male infertility: A pooled data from Iranian studies
Male infertility is a complex disease in which environmental factors and genetic background are known to be the main causes of pathogenesis. The imbalance in production and elimination of free radicals due to oxidative stress can alter the risk of infertility. There are a number of genes involved in the oxidative stress process, such as the glutathione S-transferase (GST) family of genes, which may play a critical role in combating oxidative stress in the male reproductive system. Any alteration in the structure and function of these genes may increase the risk of infertility. The aim of this study was to investigate the association between GSTM1 null genotype and male infertility in Iranian men using meta-analysis. In this study, valid databases such as Google Scholar, PubMed, SID, and Magiran were used to find appropriate studies. After electronic search and screening of studies, four appropriate studies were included in our meta-analysis. Data analysis revealed that GSTM1 null genotype correlated with increased risk of infertility in Iranian men. No publication bias was detected. Sensitivity analysis showed that exclusion of one study did not significantly affect the pooled odds ratios. These data suggest that the null genotype of GSTM1 may be a significant molecular risk factor for male infertility in the Iranian population. However, further studies with larger samples are needed to confirm the accuracy of these results.
http://www.cajmpsi.com/article_143860_90bf500f76b7b62f076f33efb774d8da.pdf
2022-02-01
1
8
10.22034/CAJMPSI.2022.01.01
Male infertility
GSTM1
genetic mutation
Meta-analysis
Amirkian
Bokharaei
bokharaeiak991@mums.ac.ir
1
Student Research Committee, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
Maryam
Sheikhi
sheikhim2@mums.ac.ir
2
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Melika
Molkizadeh
melikamolkizadeh76@gmail.com
3
Mashhad Paramedical Science Branch, Islamic Azad University, Mashhad, Iran
AUTHOR
Najmeh
Majidi
md56majidi@gmail.com
4
Department of Internal Medicine,School of Medicine,Mashhad University of Medical Sciences,Mashhad, Iran
AUTHOR
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ORIGINAL_ARTICLE
Aggressive plexiform mandibular ameloblastoma arising from a dentigerous cyst: A case report
Among odontogenic cysts, dentigerous cysts (DC) and among odontogenic tumors, ameloblastoma are the most common. Odontogenic tumors such as ameloblastoma can develop from the cyst lining of dentigerous cyst and also odontogenic keratocyst. DC is the most common form of odontogenic cyst, formed by the accumulation of fluid between the reduced enamel epithelium and the tooth crown, and is clinically associated with an unerupted tooth, most commonly an unerupted mandibular third molar, an upper canine, and a mandibular premolar.Radiographically, unilocular x-ray fluorescence with well-defined sclerotic margins surrounding the crown of an unerupted tooth is noted. Ameloblastoma is a neoplasm classified as a benign epithelial odontogenic tumor of the jaw. 70% of ameloblastomas develop in the molar-ramus region of the mandible and are occasionally associated with an unerupted third molar.Histologically, most ameloblastomas have a follicular or plexiform pattern, although basaloid, granular, or desmoplastic cellular changes may also occur. This study presents a case of aggressive plexiform mandibular ameloblastoma arising from the cyst lining of a dentigerous cyst in a 36-year-old male patient.
http://www.cajmpsi.com/article_143416_add595be65a47e32043496dda86a3de1.pdf
2022-02-01
9
14
10.22034/CAJMPSI.2022.01.02
Ameloblastoma
Dentigerous cyst
aggressive
plexiform Mandibular Ameloblastoma
Mehdi
Shahabinejad
shahabinejadm@mums.ac.ir
1
Department of Oral and Maxillofacial Pathology, Oral and Maxillofacial Diseases Research Center, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Nooshin
Mohtasham
mohtashamn@mums.ac.ir
2
Department of Oral and Maxillofacial Pathology, Oral and Maxillofacial Diseases Research Center, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Farnaz
Mohajertehran
mohajertf@mums.ac.ir
3
Department of Oral and Maxillofacial Pathology, Oral and Maxillofacial Diseases Research Center, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
Maryam
Mohammadi
maryam_mohammadi16@yahoo.com
4
Oral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
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13
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https://doi.org/10.14715/cmb/2020.66.2.3
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16
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42
ORIGINAL_ARTICLE
Design of a new immunotoxin from a part of scorpion venom for the treatment of breast cancer
Breast cancer is one of the best known cancers worldwide. It is associated with many problems due to the structural heterogeneity of the treatment process. Many patients with breast cancer (HER2) are positive. Current cancer treatment methods are not very effective in reducing mortality. However, immunotherapy is less effective in treating cancer and damages the body. Anti-cancer immunotoxins Molecules that contain an immune component that is an antibody or a binding component of an antibody, and the other part is a toxin that is a lethal compound. The anti-HER2 receptor trastuzumab is derived from a single-stranded variable fragment (scFv) that binds to part of a scorpion toxin called neurotoxin Bmk. We investigated the physicochemical properties, secondary structure, and solubility of the chimeric protein using ProtParam and GORIV, PORCalc, PepCalc, and protein-sol, respectively. The structure and solubility of the model were evaluated using PROCHECK, protein-sol, and PepCalc. ALLERTOP server was used to predict sensitivity, and mRNA stability was assessed using RNAfold. Finally, docking of immunotoxin and HER2 was performed using ClusPro server. The results showed that the chimeric protein is a protein with a stable secondary structure in solution and a three-dimensional structure, and also has a stable mRNA and can bind to HER2. The results showed a stable and soluble protein with the desired binding ability to HER2, which made it a suitable immunotoxin candidate for the treatment of breast cancer whose safety needs to be evaluated in clinical phases.
http://www.cajmpsi.com/article_143901_6becea7294b66fe2923b4dfaf7a9fef2.pdf
2022-02-01
15
24
10.22034/CAJMPSI.2022.01.03
breast cancer
Neurotoxin
Immunotoxin
scFv
Saeed
Pirmoradi
pirmoradi150@gmail.com
1
Razi Vaccine and Serum Research Institute, Agricultural Research and Training Organization (AREEO), Ahvaz, Iran
LEAD_AUTHOR
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ORIGINAL_ARTICLE
Effects of the lead, cadmium, manganese heavy metals, and magnesium oxide nanoparticles on nerve cell function in Alzheimer's and Parkinson's diseases
Nervous disorders affect the central nervous system and cause progressive impairment of the nervous system. These disorders are usually incurable and debilitating and are characterised by a loss of nerve cell function. The most common chronic neurological disorders are Parkinson's disease (PD) and Alzheimer's disease (AD). Damage to the nerves usually progresses with age, as seen in AD and PD. Although Parkinson's and Alzheimer's diseases are multifactorial, exposure to heavy metals in neurons could increase the risk of developing these diseases. Metals are essential for maintaining cellular homeostasis and life. They have critical structural, catalytic, and regulatory functions in various types of proteins such as receptors, enzymes, and transporters. However, high and toxic concentrations of metals can stimulate the formation of reactive oxygen species (ROS) via a vicious cycle by impairing mitochondrial function, leading to a reduction in ATP and eventually cell death through an apoptotic mechanism. As life expectancy increases, individuals are certainly exposed to higher metal concentrations over a long period of time, which may lead to an increase in the incidence of neurological diseases. The aim of this study was to describe the effects of heavy metals such as manganese, lead and cadmium on the progression of the neurological diseases Parkinson's and Alzheimer's disease.
http://www.cajmpsi.com/article_144439_244877f6a8bf99152a9085e092b24f9f.pdf
2022-02-01
25
36
10.22034/CAJMPSI.2022.01.04
heavy metals
Progressive neurological diseases
Neurons
Parkinson' s disease
Alzheimer' s disease
Qassim
Hassan Aubais Aljelehawy
qasemhussan@iunajaf.edu.iq
1
Department of Medical Laboratory Technique, Islamic University, Diwaniya, Iraq
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