TY - JOUR ID - 142282 TI - The role of molecular factors in gestational hypertension and the pathogenesis of preeclampsia JO - Central Asian Journal of Medical and Pharmaceutical Sciences Innovation JA - CAJMPSI LA - en SN - AU - Kamyab Hesari, Kambiz AU - Molkizadeh, Melika AU - Bokharaei, Amirkian AU - Mohajertehran, Farnaz AD - Department of Pathology, School of Medicine,Tehran University of Medical Sciences, Tehran, Iran AD - Mashhad Paramedical Science Branch, Islamic Azad University, Mashhad, Iran AD - Student Research Committee, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran AD - Department of Oral and Maxillofacial Pathology, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran Y1 - 2021 PY - 2021 VL - 1 IS - 6 SP - 264 EP - 271 KW - preeclampsia KW - blood pressure KW - risk factor KW - cytokine KW - MicroRNA DO - 10.22034/CAJMPSI.2021.06.04 N2 - Preeclampsia (PE) is classified as a systemic condition that generally develops with high blood pressure and protein excretion in pregnant women after 20 weeks. This condition is characterised by inadequate placental blood flow and damages several organs. The illness is a complicated ailment that starts with an aberrant trophoblast invasion of the uterine decidua, endothelial dysfunction, and platelet aggregation, finally leading to a faulty placenta. Defective placenta causes difficulties such as hypoxia, oxidative stress, stimulation of the mother's immune system, and some other situations. Although the specific origin of this illness has not yet been discovered, various cellular signalling pathways may be implicated in its development. One of the molecules that may be implicated in preeclampsia is the sFlt-1 molecule. This protein has an inhibitory influence on vascularization of the placenta by lowering signalling VEGF, which leads to apoptosis of foetal vascular and disrupted placenta and exchange of nutrients, which finally leads to foetal growth limitation and preeclampsia. The renin-angiotensin-aldosterone pathway, inflammatory cytokines, and the Nrf2/HO-1 pathway are also implicated in the pathophysiology of this condition. The biogenesis route of microRNAs involved in controlling gene expression might be regarded as extra variables implicated in preeclampsia. The goal of this work was to elucidate the molecular components involved in the pathophysiology of preeclampsia. UR - http://www.cajmpsi.com/article_142282.html L1 - http://www.cajmpsi.com/article_142282_783fef863f86438536c5e93718bb1127.pdf ER -