TY - JOUR ID - 163270 TI - Vitamins and male infertility: role of various vitamins versus oxidative stress JO - Central Asian Journal of Medical and Pharmaceutical Sciences Innovation JA - CAJMPSI LA - en SN - AU - Rasul, Azhar AU - Mededovic, Samra AU - Memmedov, Hikmet AU - Canan Alp Arıcı, Elifsena AD - Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, Pakistan AD - Health Care Study, Dzemal Bijedic, University of Mostar, Mostar, Bosnia & Herzegovina AD - Department of Biochemistry, Azerbaijan Medical University, Baku, Azerbaijan AD - Department of Obstetrics and Gynecology, Faculty of Medicine, Necmettin Erbakan Unıversity Meram, Konya, Türkiye Y1 - 2022 PY - 2022 VL - 2 IS - 5 SP - 151 EP - 164 KW - Male infertility KW - oxidative stress KW - Vitamins KW - Lipid peroxidation DO - 10.22034/CAJMPSI.2022.05.02 N2 - Reactive oxygen species (ROS) are necessary for regular functions of spermatozoa including acrosome reaction, capacitation, fertilization, etc. But its high amount can be harmful to the function of the sperm cell. Compared to other cells, the sperm cell is more susceptible to oxidative attacks because of the extreme concentration of unsaturated fatty acids in the plasmalemma and the minor level of the cytoplasm. A chief factor of sperm genome damage, which is involved in most kinds of infertility in men, is increased oxidative stress. Some micronutrients, such as vitamins C, E, D, B6, B9, B12, selenium, iron, zinc, and essential fatty acids could have a direct effect on fertility by reducing the ROS level and its detrimental influences on sperm parameters. In humans, the most active form of vitamin E is alpha-tocopherol and the strongest antioxidant, and its most important task is to fight lipid oxidation by free radicals. High concentration of ascorbic acid in seminal plasma probably points to its role in protection of spermatozoa from ROS attacks and preventing oxidative DNA damage. Quality of semen and specific sperm motility seem to be related to vitamin D. Vitamin A plays an important role in spermatogenesis due to its oxidative activity. Vitamins B are cofactors for the main metabolic enzymes of sperm and their deficiency can affect male fertility. The purpose of this study is to describe the role of vitamins in overcoming oxidative stress in male infertility. UR - http://www.cajmpsi.com/article_163270.html L1 - http://www.cajmpsi.com/article_163270_0c22b824c4255542c605672e0a0ca0af.pdf ER -