Study of A1298C variation in MTHFR gene as a molecular risk factor for male infertility in Iran

Document Type : Research Paper


Department of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.


Methylenetetrahydrofolate reductase is an important enzyme in folate metabolism pathway. Some studies investigated the correlation of a common gene variation (A1298C) with male infertility in a specific Caucasian population (Iran), but the outcomes are controversial. Thus, the current study employed a meta-analysis to determine the association of mentioned variation with male infertility in Iranian population. PubMed, Google Scholar, EMBASE, SID, and Magiran databases were searched to recognize eligible publications. The odds ratios (ORs) was used with corresponding 95% confidence intervals (95% CIs) to assess the strength of genetic association analysis. The data were analyzed through Metagenyo software. Generally, three qualified papers were found and included in the quantitative synthesis (meta-analysis). The obtained data displayed that the variation is not correlated with male infertility in co-dominant genetic models. Also, the results showed no significant heterogeneities among eligible included studies. Moreover, publication bias was not detected in the current analysis. A1298C polymorphism in MTHFR gene is not correlated with male infertility in Iranian population, and it could not be considered as a risk factor for male infertility.

Graphical Abstract

Study of A1298C variation in MTHFR gene as a molecular risk factor for male infertility in Iran


  • Methylene tetrahydrofolate reductase molecule could be a key enzyme in cellular processes.
  • The A1298C genetic variation is an exonic SNP in MTHFR sequence.
  • The A1298C genetic polymorphism is not correlated with male infertility risk.


Main Subjects

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