Association of inflammation with female reproductive system disorders

Document Type : Review Paper


1 Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

2 Medical Biology Research Center, Health Technology institute, Kermanshah University of Medical Sciences, Kermanshah, Iran


Inflammation is the body response against infection, injury and illness. It is a significant factor which can affect reproduction processes. Inflammatory state has key roles in physiological reproductive functions in women like menstruation, ovulation, implantation and pregnancy. Previous studies evaluated the association of inflammatory mechanisms with disorders such as ovulatory abnormalities, polycystic ovary syndrome, endometriosis, premature onset of labor and infertility in women—the present review summarized association between inflammation state and some reproductive disorders in female. Based on available findings, the inflammation state can be associated with various female reproductive disorders, which finally can affect fertility potential. Thus, assessment of inflammatory mechanisms and their association with processes of reproductive in treatment strategies of female infertility can be efficient. More comprehensive studies with a large number of patients and consideration of inflammatory pathways are required to provide more definitive evidences.

Graphical Abstract

Association of inflammation with female reproductive system disorders


  • Inflammation is the body response against injury and infection.
  • Inflammation can affect fertility potential of women.
  • Inflammatory state has essential roles in physiological reproductive functions in females.
  • Inflammatory mechanisms are associated with disorders of female reproductive system.


Main Subjects

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