C3953T genetic variation in interleukin 1β and idiopathic male infertility: a systematic review and meta-analysis

Document Type : Systematic Review

Author

Research and Development Department, Giga Biotics, San Diego, California, USA

Abstract

According to the World Health Organization, infertility means that a couple will not have children after 12 months of unprotected sex. Half of all cases of infertility are due to male factors. Environmental and genetic factors play a role in idiopathic infertility in men. Genetic polymorphisms in cytokine family genes may be an important risk factor for male infertility. This study aimed to investigate the association of C3953T polymorphism in the interleukin-1-beta gene with male infertility through a meta-analysis approach. For this study, an electronic search was conducted in reputable databases such as PubMed, Google Scholar, and Science Direct. Finally, three eligible studies were included in our meta-analysis. The results of the meta-analysis showed that C3953T polymorphism was associated with male infertility in allelic model (OR= 1.2143, 95% CI= 1.0057; 1.4662, p= 0.0433) and homozygous codominant model (OR= 3.0292, 95% CI= 1.5681; 5.8519, p= 0.00097). Another study also showed that there was no publication bias in our study and a sensitivity analysis showed that the exclusion of one study could not have a significant effect on the pooled ORs. Based on these results, the C3953T polymorphism may be a genetic risk factor for idiopathic infertility in men. However, due to the limited number of studies in this meta-analysis, further studies with higher sample sizes and different races are needed to obtain more accurate results.

Graphical Abstract

C3953T genetic variation in interleukin 1β and idiopathic male infertility: a systematic review and meta-analysis

Highlights

  • Cytokines may play an important role in the male reproductive system, and alterations in their structure and function may increase the risk of male infertility.
  • Interleukin-1-beta may affect sperm function by influencing oxidative stress.
  • The C3953T polymorphism in interleukin-1-beta may be a genetic risk factor for male infertility.

Keywords

Main Subjects


1. De Berardis D, Mazza M, Marini S, Del Nibletto L, Serroni N, Pino MC, Valchera A, Ortolani C, Ciarrocchi F, Martinotti G, Di Giannantonio M. Psychopathology, emotional aspects and psychological counselling in infertility: a review. Clin Ter 2014; 165(3): 163-169.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
2. Ghuman N, Ramalingam M. Male infertility. Obstet Gynaecol Reprod Med 2018; 28: 7-14.
3. Azenabor A, Ekun AO, Akinloye O. Impact of inflammation on male reproductive tract. J Reprod Infertil 2015; 16: 123.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
5. Syriou V, Papanikolaou D, Kozyraki A, Goulis DG. Cytokines and male infertility. Eur Cytokine Netw 2018; 29: 73-82.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
6. Griswold MD. Spermatogenesis: the commitment to meiosis. Physiol Rev 2016; 96: 1-17.
7. Fijak M, Bhushan S, Meinhardt A. Immunoprivileged sites: the testis. Methods Mol Biol 2010; 459-470.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
8. Wen L, Zhang Y, Yang B, Han F, Ebadi AG, Toughani M. Knockdown of Angiopoietin-like protein 4 suppresses the development of colorectal cancer. Cell Mol Biol 2020; 66(5): 117-124.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed     
9. Angulo C, Maldonado R, Pulgar E, Mancilla H, Córdova A, Villarroel F, Castro MA, Concha II. Vitamin C and oxidative stress in the seminiferous epithelium. Biol Res 2011; 44(2): 169-180.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
10. Mantovani A, Bussolino F, Introna M. Cytokine regulation of endothelial cell function: from molecular level to the bedside. Immunol Today 1997; 18: 238-240.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
11. Rozwadowska N, Fiszer D, Jedrzejczak P, Kosicki W, Kurpisz M. Interleukin-1 superfamily genes expression in normal or impaired human spermatogenesis. Genes Immun 2007; 8: 100-107.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
12. Fraczek M, Kurpisz M. Cytokines in the male reproductive tract and their role in infertility disorders. J Reprod Immunol 2015; 108: 98-104.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
13. Sachidanandam R, Weissman D, Schmidt SC, Kakol JM, Stein LD, Marth G, Sherry S, Mullikin JC, Mortimore BJ, Willey DL, Hunt SE. A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature 2001; 409(6822): 928-934.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
14. Bentz E-K, Hefler LA, Denschlag D, Pietrowski D, Buerkle B, Tempfer CB. A polymorphism of the interleukin-1 beta gene is associated with sperm pathology in humans. Fertil Steril 2007; 88(3): 751-753.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
15. Jaiswal D, Trivedi S, Agrawal NK, Singh R, Singh K. Association of interleukin-1beta C+ 3953T gene polymorphism with human male infertility. Syst Biol Reprod Med 2013; 59(6): 347-351.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
16. Zamani-Badi T, Karimian M, Azami-Tameh A, Nikzad H. Association of C3953T transition in interleukin 1β gene with idiopathic male infertility in an Iranian population. Hum Fertil 2019; 22: 111-117.
17. Poongothai J, Gopenath T, Manonayaki S. Genetics of human male infertility. Singapore Med J 2009; 50(4): 336-347.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
18. Yang M, Abdalrahman H, Sonia U, Mohammed AI, Vestine U, Wang M, Ebadi AG, Toughani M. The application of DNA molecular markers in the study of Codonopsis species genetic variation, a review. Cell Mol Biol 2020; 66(2): 23-30.
19. Heinrich A, DeFalco T. Essential roles of interstitial cells in testicular development and function. Andrology 2020; 8(4): 903-914.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed    
20. Meroni SB, Galardo MN, Rindone G, Gorga A, Riera MF, Cigorraga SB. Molecular mechanisms and signaling pathways involved in sertoli cell proliferation. Front Endocrinol 2019; 10: 224.
21. Agarwal A, Virk G, Ong C, Du Plessis SS. Effect of oxidative stress on male reproduction. World J Men Health 2014; 32(1): 1-7.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed