Association of glutathione S-transferase M1 null mutation with male infertility: A pooled data from Iranian studies

Document Type : Systematic Review

Authors

1 Student Research Committee, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran

2 Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

3 Mashhad Paramedical Science Branch, Islamic Azad University, Mashhad, Iran

4 Department of Internal Medicine,School of Medicine,Mashhad University of Medical Sciences,Mashhad, Iran

Abstract

Male infertility is a complex disease in which environmental factors and genetic background are known to be the main causes of pathogenesis. The imbalance in production and elimination of free radicals due to oxidative stress can alter the risk of infertility. There are a number of genes involved in the oxidative stress process, such as the glutathione S-transferase (GST) family of genes, which may play a critical role in combating oxidative stress in the male reproductive system. Any alteration in the structure and function of these genes may increase the risk of infertility. The aim of this study was to investigate the association between GSTM1 null genotype and male infertility in Iranian men using meta-analysis. In this study, valid databases such as Google Scholar, PubMed, SID, and Magiran were used to find appropriate studies. After electronic search and screening of studies, four appropriate studies were included in our meta-analysis. Data analysis revealed that GSTM1 null genotype correlated with increased risk of infertility in Iranian men. No publication bias was detected. Sensitivity analysis showed that exclusion of one study did not significantly affect the pooled odds ratios. These data suggest that the null genotype of GSTM1 may be a significant molecular risk factor for male infertility in the Iranian population. However, further studies with larger samples are needed to confirm the accuracy of these results.

Graphical Abstract

Association of glutathione S-transferase M1 null mutation with male infertility: A pooled data from Iranian studies

Highlights

  • Male infertility is a main public health concern which can affect the couple's life.
  • Male infertility could be affected by both genetic and environmental factors.
  • Stress oxidative and the related genes involved in this process may influence male infertility.
  • Null mutation in GSTM1 as an antioxidant gene could be a considerable risk factor for idiopathic cause of male infertility in Iranian men.

Keywords

Main Subjects

References

1. Deshpande PS, Gupta AS. Causes and prevalence of factors causing infertility in a public health facility. J Hum Reprod Sci 2019; 12: 287-293.
https://doi.oeg/10.4103/jhrs.JHRS_140_18
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed    PubMed Central
2. Poongothai J, Gopenath T, Manonayaki S. Genetics of human male infertility. Singapore Med J 2009; 50: 336-347.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
3. Virtanen HE, Jørgensen N, Toppari J. Semen quality in the 21(st) century. Nat Rev Urol 2017; 14: 120-130.
https://doi.org/10.1038/nrurol.2016.261
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
4. Agarwal A, Said TM. Oxidative stress, DNA damage and apoptosis in male infertility: a clinical approach. BJU Int 2005; 95: 503-507.
https://doi.org/10.1111/j.1464-410X.2005.05328.x
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
5. Jancova P, Anzenbacher P, Anzenbacherova E. Phase II drug metabolizing enzymes. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2010; 154: 103-116.
https://doi.org/10.5507/bp.2010.017
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
6. Al-Gubory KH, Fowler PA, Garrel C. The roles of cellular reactive oxygen species, oxidative stress and antioxidants in pregnancy outcomes. Int J Biochem Cell Biol 2010; 42(10): 1634-1650.
https://doi.org/10.1016/j.biocel.2010.06.001
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
7. Hayes JD, Flanagan JU, Jowsey IR. Glutathione transferases. Annu Rev Pharmacol Toxicol 2005; 45: 51-88.
https://doi.org/10.1146/annurev.pharmtox.45.120403.095857
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
8. Jiang S, Yu L, Cheng J, Leng S, Dai Y, Zhang Y, Niu Y, Yan H, Qu W, Zhang C, Zhang K. Genomic damages in peripheral blood lymphocytes and association with polymorphisms of three glutathione S-transferases in workers exposed to formaldehyde. Mutat Res Genet Toxicol Environ Mutagen 2010; 695(1-2): 9-15.
https://doi.org/10.1016/j.mrgentox.2009.09.011
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
9. Tirumala Vani G, Mukesh N, Siva Prasad B, Rama Devi P, Hema Prasad M, Usha Rani P, Pardhanandana Reddy P. Role of glutathione S‐transferase Mu‐1 (GSTM1) polymorphism in oligospermic infertile males. Andrologia 2010; 42: 213-217.
https://doi.org/10.1111/j.1439-0272.2009.00971.x
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
10. Olshan AF, Luben TJ, Hanley NM, Perreault SD, Chan RL, Herring AH, Basta PV, DeMarini DM. Preliminary examination of polymorphisms of GSTM1, GSTT1, and GSTZ1 in relation to semen quality. Mutat Res 2010; 688: 41-46.
https://doi.org/10.1016/j.mrfmmm.2010.03.002
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed    PubMed Central
11. Wu QF, Xing JP, Tang KF, Xue W, Liu M, Sun JH, Wang XY, Jin XJ. Genetic polymorphism of glutathione S‐transferase T1 gene and susceptibility to idiopathic azoospermia or oligospermia in northwestern China. Asian J Androl 2008; 10: 266-270.
https://doi.org/10.1111/j.1745-7262.2008.00347.x
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
12. Tang K, Xue W, Xing Y, Xu S, Wu Q, Liu R, Wang X, Xing J. Genetic polymorphisms of glutathione S‐transferase M1, T1, and P1, and the assessment of oxidative damage in infertile men with varicoceles from northwestern China. J Androl 2012; 33: 257-263.
https://doi.org/10.2164/jandrol.110.012468
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
13. Safarinejad MR, Shafiei N, Safarinejad S. The association of glutathione-S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) with idiopathic male infertility. J Hum Genet 2010; 55: 565-570.
https://doi.org/10.1038/jhg.2010.59
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
14. Salehi Z, Gholizadeh L, Vaziri H, Madani AH. Analysis of GSTM1, GSTT1, and CYP1A1 in idiopathic male infertility. Reprod Sci 2012; 19: 81-85.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
15. Fatahi E, Safinejad K, Mehrabi M. Association of glutathione s-transferase m1 and t1 polymorphisms with severe oligozoospermia. Stud Med Sci 2016; 26: 844-851.
CrossRef    Google Scholar    full-text PDF    Mendeley   
16. Barati E, Karimian M, Nikzad H. Oxidative stress markers in seminal plasma of idiopathic infertile men may be associated with glutathione S-transferase M1 and T1 null genotypes. Andrologia 2020; 52: e13703.
https://doi.org/10.1111/and.13703
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
17. Feng HL. Molecular biology of male infertility. Arch Androl 2003; 49: 19-27.
https://doi.org/10.1080/01485010290031556-1
CrossRef    Google Scholar    full-text PDF    Mendeley   
18. Elfateh F, Wang R, Zhang Z, Jiang Y, Chen S, Liu R. Influence of genetic abnormalities on semen quality and male fertility: A four-year prospective study. Iran J Reprod Med 2014; 12: 95-102.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed    PubMed Central
19. Bansal AK, Bilaspuri GS. Impacts of oxidative stress and antioxidants on semen functions. Vet Med Int 2010; 2010.
https://doi.org/10.4061/2011/686137
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed    PubMed Central
20. Yu B, Huang Z. Variations in Antioxidant Genes and Male Infertility. BioMed Res Int 2015; 2015: 513196.
https://doi.org/10.1155/2015/513196
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed    PubMed Central
21. Kobayashi M, Yamamoto M. Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation. Antioxid Redox Signal 2005; 7(3-4): 385-394.
https://doi.org/10.1089/ars.2005.7.385
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
22. Li Y, Cao Y, Wang F, Li C. Scrotal heat induced the Nrf2-driven antioxidant response during oxidative stress and apoptosis in the mouse testis. Acta Histochem 2014; 116(5): 883-890.
https://doi.org/10.1016/j.acthis.2014.02.008
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
23. García Rodríguez A, de la Casa M, Johnston S, Gosálvez J, Roy R. Association of polymorphisms in genes coding for antioxidant enzymes and human male infertility. Ann Hum Genet 2019; 83(1): 63-72.
https://doi.org/10.1111/ahg.12286
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
24. Mahbouli S, Dupont C, Elfassy Y, Lameignère E, Levy R. Exploring the potential impact of nutritionally actionable genetic polymorphisms on idiopathic male infertility: a review of current evidence. Asian J Androl 2021; 23: 441-449.
https://doi.org/10.4103/aja.aja_87_20
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
25. Fafula RV, Paranyak NM, Besedina AS, Vorobets DZ, Iefremova UP, Onufrovych OK, Vorobets ZD. Biological Significance of Glutathione S-Transferases in Human Sperm Cells. J Hum Reprod Sci 2019; 12(1): 24-28.
https://doi.org/10.4103/jhrs.JHRS_106_18
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed    PubMed Central
26. Hashemi M, Eskandari-Nasab E, Fazaeli A, Taheri M, Rezaei H, Mashhadi M, Arbabi F, Kaykhaei MA, Jahantigh M, Bahari G. Association between polymorphisms of glutathione S-transferase genes (GSTM1, GSTP1 and GSTT1) and breast cancer risk in a sample Iranian population. Biomarkers Med 2012; 6(6): 797-803.
https://doi.org/10.2217/bmm.12.61
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed 
27. Wen L, Zhang Y, Yang B, Han F, Ebadi AG, Toughani M. Knockdown of Angiopoietin-like protein 4 suppresses the development of colorectal cancer. Cell Mol Biol 2020; 66(5): 117-124.
https://doi.org/10.14715/cmb/2020.66.5.21
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed        
28. Maselli J, Hales BF, Chan P, Robaire B. Exposure to bleomycin, etoposide, and cis-platinum alters rat sperm chromatin integrity and sperm head protein profile. Biol Reprod 2012; 86(5): 166-171.
https://doi.org/10.1095/biolreprod.111.098616
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed    PubMed Central
29. Hemachand T, Shaha C. Functional role of sperm surface glutathione S-transferases and extracellular glutathione in the haploid spermatozoa under oxidative stress. FEBS Lett 2003; 538 (1-3): 14-18.
https://doi.org/10.1016/S0014-5793(03)00103-0
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
30. Hemachand T, Gopalakrishnan B, Salunke DM, Totey SM, Shaha C. Sperm plasma-membrane-associated glutathione S-transferases as gamete recognition molecules. J Cell Sci 2002; 115(10): 2053-2065.
https://doi.org/10.1242/jcs.115.10.2053
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
31. Gopalakrishnan B, Aravinda S, Pawshe CH, Totey SM, Nagpal S, Salunke DM, Shaha C. Studies on glutathione S-transferases important for sperm function: evidence of catalytic activity-independent functions. Biochem J 1998; 329(2): 231-241.
https://doi.org/10.1042/bj3290231
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed    PubMed Central
32. Yang M, Abdalrahman H, Sonia U, Mohammed AI, Vestine U, Wang M, Ebadi AG, Toughani M. The application of DNA molecular markers in the study of Codonopsis species genetic variation, a review. Cell Mol Biol 2020; 66(2): 23-30.
https://doi.org/10.14715/cmb/2020.66.2.3
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
33. Llavanera M, Mateo-Otero Y, Bonet S, Barranco I, Fernández-Fuertes B, Yeste M. The triple role of glutathione S-transferases in mammalian male fertility. Cell Mol life Sci 2020; 77(12): 2331-2342.
https://doi.org/10.1007/s00018-019-03405-w
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
Central Asian Journal of Medical and Pharmaceutical Sciences Innovation
Volume 2, Issue 1
January and February 2022
Pages 1-8

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