Effects of the lead, cadmium, manganese heavy metals, and magnesium oxide nanoparticles on nerve cell function in Alzheimer's and Parkinson's diseases

Hassan Aubais Aljelehawy, Qassim

doi:10.22034/CAJMPSI.2022.01.04

Effects of the lead, cadmium, manganese heavy metals, and magnesium oxide nanoparticles on nerve cell function in Alzheimer's and Parkinson's diseases

Document Type : Review Paper

Author

Qassim Hassan Aubais Aljelehawy

Department of Medical Laboratory Technique, Islamic University, Diwaniya, Iraq

10.22034/CAJMPSI.2022.01.04

Abstract

Nervous disorders affect the central nervous system and cause progressive impairment of the nervous system. These disorders are usually incurable and debilitating and are characterised by a loss of nerve cell function. The most common chronic neurological disorders are Parkinson's disease (PD) and Alzheimer's disease (AD). Damage to the nerves usually progresses with age, as seen in AD and PD. Although Parkinson's and Alzheimer's diseases are multifactorial, exposure to heavy metals in neurons could increase the risk of developing these diseases. Metals are essential for maintaining cellular homeostasis and life. They have critical structural, catalytic, and regulatory functions in various types of proteins such as receptors, enzymes, and transporters. However, high and toxic concentrations of metals can stimulate the formation of reactive oxygen species (ROS) via a vicious cycle by impairing mitochondrial function, leading to a reduction in ATP and eventually cell death through an apoptotic mechanism. As life expectancy increases, individuals are certainly exposed to higher metal concentrations over a long period of time, which may lead to an increase in the incidence of neurological diseases. The aim of this study was to describe the effects of heavy metals such as manganese, lead and cadmium on the progression of the neurological diseases Parkinson's and Alzheimer's disease.

Graphical Abstract

Highlights

Alzheimer's and Parkinson's diseases are multifactorial diseases.
The risk of developing Alzheimer's and Parkinson's increases with exposure to heavy metals.
High and toxic levels of metals can impair mitochondrial function.
Heavy metals could produce reactive oxygen species and activate apoptosis.

Keywords

Main Subjects

Biomedicine

References

1. Eisen A, Turner MR. Does variation in neurodegenerative disease susceptibility and phenotype reflect cerebral differences at the network level?. Amyotroph Lateral Scler Front Deg 2013; 14(7-8): 487-493.

https://doi.org/10.3109/21678421.2013.812660

CrossRef Google Scholar full-text PDF Mendeley PubMed

2. Fathi A, Barak M, Damandan M, Amani F, Moradpour R, Khalilova I, Valizadeh M. Neonatal Screening for Glucose-6-phosphate dehydrogenase Deficiency in Ardabil Province, Iran, 2018-2019. Cell Mol Biomed Rep 2021; 1(1): 1-6.

CrossRef Google Scholar full-text PDF Mendeley

3. Azeez SH, Jafar SN, Aziziaram Z, Fang L, Mawlood AH, Ercisli MF. Insulin-producing cells from bone marrow stem cells versus injectable insulin for the treatment of rats with type I diabetes. Cell Mol Biomed Rep 2021; 1(1): 42-51.

CrossRef Google Scholar full-text PDF Mendeley

4. Magistretti PJ, Allaman I. A cellular perspective on brain energy metabolism and functional imaging. Neuron 2015; 86(4): 883-901.

https://doi.org/10.1016/j.neuron.2015.03.035

CrossRef Google Scholar full-text PDF Mendeley PubMed

5. Davis GW, Bezprozvanny I. Maintaining the stability of neural function: a homeostatic hypothesis. Annu Rev Physiol 2001; 63(1): 847-869.

https://doi.org/10.1146/annurev.physiol.63.1.847

CrossRef Google Scholar full-text PDF Mendeley PubMed

6. Emsley JG, Mitchell BD, Kempermann G, Macklis JD. Adult neurogenesis and repair of the adult CNS with neural progenitors, precursors, and stem cells. Prog Neurobiol 2005; 75(5): 321-41.

https://doi.org/10.1016/j.pneurobio.2005.04.002

CrossRef Google Scholar full-text PDF Mendeley PubMed

7. Parpura V, Heneka MT, Montana V, Oliet SH, Schousboe A, Haydon PG, Stout Jr RF, Spray DC, Reichenbach A, Pannicke T, Pekny M. Glial cells in (patho) physiology. J Neurochem 2012; 121(1): 4-27.

https://doi.org/10.1111/j.1471-4159.2012.07664.x

CrossRef Google Scholar full-text PDF Mendeley PubMed PubMed Central

8. Cavaleri F. Review of Amyotrophic Lateral Sclerosis, Parkinson’s and Alzheimer’s diseases helps further define pathology of the novel paradigm for Alzheimer’s with heavy metals as primary disease cause. Med Hypotheses 2015; 85(6): 779-790.

https://doi.org/10.1016/j.mehy.2015.10.009

CrossRef Google Scholar full-text PDF Mendeley PubMed

9. Bakulski KM, Seo YA, Hickman RC, Brandt D, Vadari HS, Hu H, KyunPark S. Heavy metals exposure and Alzheimer’s disease and related dementias. J Alzheimer's Dis 2020; 1-28.

https://doi.org/10.3233/JAD-200282

CrossRef Google Scholar full-text PDF Mendeley PubMed PubMed Central

10. Guan C, Dang R, Cui Y, Liu L, Chen X, Wang X, Zhu J, Li D, Li J, Wang D. Characterization of plasma metal profiles in Alzheimer’s disease using multivariate statistical analysis. Plos One 2017; 12(7): e0178271.

https://doi.org/10.1371/journal.pone.0178271

CrossRef Google Scholar full-text PDF Mendeley PubMed PubMed Central

11. Olanow CW, Arendash GW. Metals and free radicals in neurodegeneration. Curr Opin Neurol 1994; 7(6): 548-558.

https://doi.org/10.1097/00019052-199412000-00013

CrossRef Google Scholar full-text PDF Mendeley PubMed

12. Jaishankar M, Tseten T, Anbalagan N, Mathew BB, Beeregowda KN. Toxicity, mechanism and health effects of some heavy metals. Interdiscip Toxicol 2014; 7(2): 60-72.

https://doi.org/10.2478/intox-2014-0009

CrossRef Google Scholar full-text PDF Mendeley PubMed PubMed Central

13. Starakis I, Panos G, Koutras A, E Mazokopakis E. Pathogens and chronic or long-term neurologic disorders. Cardiovasc Hematol Disord Drug Targets 2011; 11(1): 40-52.

https://doi.org/10.2174/187152911795945123

CrossRef Google Scholar full-text PDF Mendeley PubMed

14. Chen P, Miah MR, Aschner M. Metals and neurodegeneration. F1000Research. 2016; 5.

https://doi.org/10.12688/f1000research.7431.1

CrossRef Google Scholar full-text PDF Mendeley PubMed PubMed Central

15. Farina M, Avila DS, Da Rocha JB, Aschner M. Metals, oxidative stress and neurodegeneration: a focus on iron, manganese and mercury. Neurochem Int 2013; 62(5): 575-594.

https://doi.org/10.1016/j.neuint.2012.12.006

CrossRef Google Scholar full-text PDF Mendeley PubMed PubMed Central

16. Breijyeh Z, Karaman R. Comprehensive review on Alzheimer’s disease: Causes and treatment. Molecules 2020; 25(24): 5789.

https://doi.org/10.3390/molecules25245789

CrossRef Google Scholar full-text PDF Mendeley PubMed

17. Armstrong RA. The molecular biology of senile plaques and neurofibrillary tangles in Alzheimer’s disease. Folia Neuropathol 2009; 47(4): 289-299.

CrossRef Google Scholar full-text PDF Mendeley PubMed

18. Stokin GB, Goldstein LS. Axonal transport and Alzheimer's disease. Annu Rev Biochem 2006; 75: 607-627.

https://doi.org/10.1146/annurev.biochem.75.103004.142637

CrossRef Google Scholar full-text PDF Mendeley PubMed

19. Savelieff MG, Lee S, Liu Y, Lim MH. Untangling amyloid-β, tau, and metals in Alzheimer’s disease. ACS Chem Biol 2013; 8(5): 856-865.

https://doi.org/10.1021/cb400080f

CrossRef Google Scholar full-text PDF Mendeley PubMed

20. Thomas P, Fenech M. A review of genome mutation and Alzheimer's disease. Mutagenesis 2007; 22(1): 15-33.

https://doi.org/10.1093/mutage/gel055

CrossRef Google Scholar full-text PDF Mendeley PubMed

21. Oakley H, Cole SL, Logan S, Maus E, Shao P, Craft J, Guillozet-Bongaarts A, Ohno M, Disterhoft J, Van Eldik L, Berry R. Intraneuronal β-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. J Neurosci 2006; 26(40): 10129-10140.

https://doi.org/10.1523/JNEUROSCI.1202-06.2006

CrossRef Google Scholar full-text PDF Mendeley PubMed PubMed Central

22. Mullane K, Williams M. Alzheimer’s disease beyond amyloid: Can the repetitive failures of amyloid-targeted therapeutics inform future approaches to dementia drug discovery?. Biochem Pharmacol 2020; 177: 113945.

https://doi.org/10.1016/j.bcp.2020.113945

CrossRef Google Scholar full-text PDF Mendeley PubMed

23. Prokop S, Miller KR, Heppner FL. Microglia actions in Alzheimer’s disease. Acta Neuropathol 2013; 126(4): 461-477.

https://doi.org/10.1007/s00401-013-1182-x

CrossRef Google Scholar full-text PDF Mendeley PubMed

24. Yeh FL, Hansen DV, Sheng M. TREM2, microglia, and neurodegenerative diseases. Trends Mol Med 2017; 23(6): 512-533.

https://doi.org/10.1016/j.molmed.2017.03.008

CrossRef Google Scholar full-text PDF Mendeley PubMed

25. Streit WJ, Kincaid-Colton CA. The brain’s immune system. Sci Am 1995; 273(5): 54-61.

https://doi.org/10.1038/scientificamerican1195-54

CrossRef Google Scholar full-text PDF Mendeley PubMed

26. Fakhoury M. Microglia and astrocytes in Alzheimer's disease: implications for therapy. Curr Neuropharmacol 2018; 16(5): 508-518.

https://doi.org/10.2174/1570159X15666170720095240

CrossRef Google Scholar full-text PDF Mendeley PubMed PubMed Central

27. Radhakrishnan DM, Goyal V. Parkinson's disease: A review. Neurol India 2018; 66(7): 26.

https://doi.org/10.4103/0028-3886.226451

CrossRef Google Scholar full-text PDF Mendeley PubMed

28. Wong SL, Gilmour H, Ramage-Morin PL. Parkinson's disease: Prevalence, diagnosis and impact. Health Rep 2014; 25(11): 10-14.

CrossRef Google Scholar full-text PDF Mendeley PubMed

29. Mishra AK, Dixit A. Dopaminergic Axons: Key Recitalists in Parkinson’s Disease. Neurochem Res 2021: 1-5.

https://doi.org/10.1007/s11064-021-03464-1

CrossRef Google Scholar full-text PDF Mendeley PubMed

30. Kumakura K. Molecular mechanisms for neurotransmitter release. Tanpakushitsu kakusan koso. Protein Nucleic Acid Enzyme 1997; 42(3 Suppl): 261-274.

https://doi.org/10.1007/978-1-59745-481-0

CrossRef Google Scholar full-text PDF Mendeley PubMed

31. Blandini F, Nappi G, Tassorelli C, Martignoni E. Functional changes of the basal ganglia circuitry in Parkinson's disease. Prog Neurobiol 2000; 62(1): 63-88.

https://doi.org/10.1016/S0301-0082(99)00067-2

CrossRef Google Scholar full-text PDF Mendeley PubMed

32. McAuley JH. The physiological basis of clinical deficits in Parkinson’s disease. Prog Neurobiol 2003; 69(1): 27-48.

https://doi.org/10.1016/S0301-0082(03)00003-0

CrossRef Google Scholar full-text PDF Mendeley PubMed

33. Çakir Y. Modeling influences of dopamine on synchronization behavior of striatum. Netw Comput Neural Syst 2017; 28(1): 28-52.

https://doi.org/10.1080/0954898X.2017.1378824

CrossRef Google Scholar full-text PDF Mendeley PubMed

34. Vennam S, Georgoulas S, Khawaja A, Chua S, Strouthidis NG, Foster PJ. Heavy metal toxicity and the aetiology of glaucoma. Eye 2020; 34(1): 129-137.

https://doi.org/10.1038/s41433-019-0672-z

CrossRef Google Scholar full-text PDF Mendeley PubMed PubMed Central

35. Gidlow DA. Lead toxicity. Occup Med 2015; 65(5): 348-356.

https://doi.org/10.1093/occmed/kqv170

CrossRef Google Scholar full-text PDF Mendeley PubMed

36. Papanikolaou NC, Hatzidaki EG, Belivanis S, Tzanakakis GN, Tsatsakis AM. Lead toxicity update. A brief review. Med Sci Monit 2005; 11(10): RA329.

CrossRef Google Scholar full-text PDF Mendeley PubMed

37. Onalaja AO, Claudio L. Genetic susceptibility to lead poisoning. Environ Health Perspect 2000; 108(suppl 1): 23-28.

https://doi.org/10.1289/ehp.00108s123

CrossRef Google Scholar full-text PDF Mendeley PubMed PubMed Central

38. Abbott NJ, Rönnbäck L, Hansson E. Astrocyte–endothelial interactions at the blood–brain barrier. Nat Rev Neurosci 2006; 7(1): 41-53.

https://doi.org/10.1038/nrn1824

CrossRef Google Scholar full-text PDF Mendeley PubMed

39. Huat TJ, Camats-Perna J, Newcombe EA, Valmas N, Kitazawa M, Medeiros R. Metal toxicity links to Alzheimer's disease and neuroinflammation. J Mol Biol 2019; 431(9): 1843-1868.

https://doi.org/10.1016/j.jmb.2019.01.018

CrossRef Google Scholar full-text PDF Mendeley PubMed PubMed Central

40. Garza A, Vega R, Soto E. Cellular mechanisms of lead neurotoxicity. Med Sci Monit 2006; 12(3): RA57-RA65.

CrossRef Google Scholar full-text PDF Mendeley PubMed

41. Antonio MT, Corpas I, Leret ML. Neurochemical changes in newborn rat’s brain after gestational cadmium and lead exposure. Toxicol Lett 1999; 104(1-2): 1-9.

https://doi.org/10.1016/S0378-4274(98)00125-8

CrossRef Google Scholar full-text PDF Mendeley PubMed

42. Braun AP, Schulman H. The multifunctional calcium/calmodulin-dependent protein kinase: from form to function. Annu Rev Physiol 1995; 57(1): 417-445.

https://doi.org/10.1146/annurev.ph.57.030195.002221

CrossRef Google Scholar full-text PDF Mendeley PubMed

43. Jomova K, Vondrakova D, Lawson M, Valko M. Metals, oxidative stress and neurodegenerative disorders. Mol Cell Biochem 2010; 345(1): 91-104.

https://doi.org/10.1007/s11010-010-0563-x

CrossRef Google Scholar full-text PDF Mendeley PubMed

44. Tönnies E, Trushina E. Oxidative stress, synaptic dysfunction, and Alzheimer’s disease. J Alzheimer's Dis 2017; 57(4): 1105-1121.

https://doi.org/10.3233/JAD-161088

CrossRef Google Scholar full-text PDF Mendeley PubMed PubMed Central

45. Waisberg M, Joseph P, Hale B, Beyersmann D. Molecular and cellular mechanisms of cadmium carcinogenesis. Toxicology 2003; 192(2-3): 95-117.

https://doi.org/10.1016/S0300-483X(03)00305-6

CrossRef Google Scholar full-text PDF Mendeley PubMed

46. Waalkes MP. Cadmium carcinogenesis. Mutat Res Fundam Mol Mech Mutagen 2003; 533(1-2): 107-120.

https://doi.org/10.1016/j.mrfmmm.2003.07.011

CrossRef Google Scholar full-text PDF Mendeley PubMed

47. Ek CJ, Dziegielewska KM, Habgood MD, Saunders NR. Barriers in the developing brain and Neurotoxicology. Neurotoxicology 2012; 33(3): 586-604.

https://doi.org/10.1016/j.neuro.2011.12.009

CrossRef Google Scholar full-text PDF Mendeley PubMed

48. Wang B, Du Y. Cadmium and its neurotoxic effects. Oxid Med Cell Longev 2013; 2013: 898034.

https://doi.org/10.1155/2013/898034

CrossRef Google Scholar full-text PDF Mendeley PubMed PubMed Central

49. del Pino J, Moyano P, Anadon MJ, García JM, Díaz MJ, García J, Frejo MT. Acute and long-term exposure to chlorpyrifos induces cell death of basal forebrain cholinergic neurons through AChE variants alteration. Toxicology 2015; 336: 1-9.

https://doi.org/10.1016/j.tox.2015.07.004

CrossRef Google Scholar full-text PDF Mendeley PubMed

50. Raj K, Kaur P, Gupta GD, Singh S. Metals associated Neurodegeneration in Parkinson's disease: Insight to Physiological, Pathological mechanisms and Management. Neurosci Lett 2021; 135873.

https://doi.org/10.1016/j.neulet.2021.135873

CrossRef Google Scholar full-text PDF Mendeley PubMed

51. Zoroddu MA, Aaseth J, Crisponi G, Medici S, Peana M, Nurchi VM. The essential metals for humans: a brief overview. J Inorg Biochem 2019; 195: 120-129.

https://doi.org/10.1016/j.jinorgbio.2019.03.013

CrossRef Google Scholar full-text PDF Mendeley PubMed

52. Chen P, Chakraborty S, Mukhopadhyay S, Lee E, Paoliello MM, Bowman AB, Aschner M. Manganese homeostasis in the nervous system. J Neurochem 2015; 134(4): 601-610.

https://doi.org/10.1111/jnc.13170

CrossRef Google Scholar full-text PDF Mendeley PubMed PubMed Central

53. Erikson KM, Syversen T, Aschner JL, Aschner M. Interactions between excessive manganese exposures and dietary iron-deficiency in neurodegeneration. Environ Toxicol Pharmacol 2005; 19(3): 415-421.

https://doi.org/10.1016/j.etap.2004.12.053

CrossRef Google Scholar full-text PDF Mendeley PubMed

54. Melina V, Craig W, Levin S. Position of the Academy of Nutrition and Dietetics: vegetarian diets. J Acad Nutr Diet 2016; 116(12): 1970-1980.

https://doi.org/10.1016/j.jand.2016.09.025

CrossRef Google Scholar full-text PDF Mendeley PubMed

55. Michalke B, Fernsebner K. New insights into manganese toxicity and speciation. J Trace Elem Med Biol 2014; 28(2): 106-116.

https://doi.org/10.1016/j.jtemb.2013.08.005

CrossRef Google Scholar full-text PDF Mendeley PubMed

56. Takeda A. Manganese action in brain function. Brain Res Rev 2003; 41(1): 79-87.

https://doi.org/10.1016/S0165-0173(02)00234-5

CrossRef Google Scholar full-text PDF Mendeley PubMed

57. O’Neal SL, Zheng W. Manganese toxicity upon overexposure: a decade in review. Curr Environ Health Rep 2015; 2(3): 315-328.

https://doi.org/10.1007/s40572-015-0056-x

CrossRef Google Scholar full-text PDF Mendeley PubMed PubMed Central

58. Xin Y, Gao H, Wang J, Qiang Y, Imam MU, Li Y, Wang J, Zhang R, Zhang H, Yu Y, Wang H. Manganese transporter Slc39a14 deficiency revealed its key role in maintaining manganese homeostasis in mice. Cell Discov 2017; 3(1): 1-3.

https://doi.org/10.1038/celldisc.2017.25

CrossRef Google Scholar full-text PDF Mendeley PubMed PubMed Central

59. Mercadante CJ, Prajapati M, Conboy HL, Dash ME, Herrera C, Pettiglio MA, Cintron-Rivera L, Salesky MA, Rao DB, Bartnikas TB. Manganese transporter Slc30a10 controls physiological manganese excretion and toxicity. J Clin Investig 2019; 129(12): 5442-5461.

https://doi.org/10.1172/JCI129710

CrossRef Google Scholar full-text PDF Mendeley PubMed PubMed Central

60. Fujishiro H, Himeno S. New Insights into the Roles of ZIP8, a Cadmium and Manganese Transporter, and Its Relation to Human Diseases. Biol Pharm Bull 2019; 42(7): 1076-1082.

https://doi.org/10.1248/bpb.b18-00637

CrossRef Google Scholar full-text PDF Mendeley PubMed PubMed Central

61. Martinez-Finley EJ, Gavin CE, Aschner M, Gunter TE. Manganese neurotoxicity and the role of reactive oxygen species. Free Radic Biol Med 2013; 62: 65-75.

https://doi.org/10.1016/j.freeradbiomed.2013.01.032

CrossRef Google Scholar full-text PDF Mendeley PubMed PubMed Central

62. Halliwell B. Role of free radicals in the neurodegenerative diseases. Drug Aging 2001; 18(9): 685-716.

https://doi.org/10.2165/00002512-200118090-00004

CrossRef Google Scholar full-text PDF Mendeley PubMed

63. Chen Z, Zhong C. Oxidative stress in Alzheimer’s disease. Neurosci Bull 2014; 30(2): 271-281.