Document Type : Research Paper
Department of Psychiatry, Center for Healthy Brain Ageing, University of New South Wales, Sydney, Australia
Department of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University, Istanbul, Türkiye
Department of Biology, Faculty of Science, Sivas Cumhuriyet University, Sivas, Türkiye
Department of Biochemistry, Faculty of Science, Sivas Cumhuriyet University, Sivas, Türkiye
Department of Biochemistry, Liaquat University of Medical & Health Sciences, Jamshoro Sindh, Pakistan
Stroke is a disease that can lead to death or long-term disability. Genetic polymorphisms in key genes can alter the risk of developing the disease. The aim of this study was to investigate the association of rs1800470 polymorphism in the TGFB1 gene with the risk of stroke in the Asian population by a meta-analysis approach. In this study, six eligible studies were included using a systematic search. The strength of the association of the polymorphism with the risk of stroke was assessed by estimating the odds ratio (OR) and 95% confidence interval (CI). The results of our study showed that rs1800470 with risk of stroke in seven genetic models’ allelic model, recessive model, dominant model, overdominant model, CC vs. TT, CC vs. CT, and CT vs. TT is not associated. Of course, there was significant heterogeneity among the included studies and there was no publication bias in the meta-analysis. Based on these results, rs1800470 polymorphism cannot be considered a suitable biomarker for stroke risk in the Asian population, and further studies are needed to achieve more accurate results.
- TGFB1 gene could be involved in the pathogenesis of stroke risk.
- The rs1800470 is a common polymorphism on TGFB1 gene.
- The rs1800470 polymorphism is not a risk factor for ischemia in Asian population.