Anti-inflammatory influences of royal jelly and melittin and their effectiveness on wound healing

Document Type : Review Paper

Authors

1 Department of Chemistry, Lovely Professional University, Punjab, India

2 Department of Medical Biology, Faculty of Medicine, Nigde Ömer Halisdemir University, Campus, Nigde, Turkiye

10.22034/CAJMPSI.2023.02.02

Abstract

Royal jelly is a valuable medicinal substance that has different biological functions in various tissues and cells and has many medicinal features including anti-allergic, anti-tumor, antioxidant, and anti-inflammatory activities and also has protective effects on the immune, reproductive, nervous, and vascular systems. Melittin, which is a peptide with 26 residues, is the key element of honey bee venom and has cytotoxic, antibacterial, anticancer, and anti-inflammatory effects. Royal jelly can ameliorate the inflammatory response in microglia through the inhibition of p38 phosphorylation, and by inhibiting the NF-KB nuclear translocation. By decreasing the secretion of pro-inflammatory molecules including TNF-α, IL-1ß, and NO, melittin could apply the anti-inflammatory impacts on several kinds of cells including microglial cells. Royal jelly components may enhance the healing of wound via an anti-inflammatory effect, promotion of the growth factors synthesis, or the fibroblasts or skin keratinocytes migration. Based on multiple biological and pharmacological activities, a kind of formulated melittin is possibly capable to promote the healing of wound. The aim of this review is to narrate the anti-inflammatory effects of royal jelly and melittin and their efficiency on wound healing.

Graphical Abstract

Anti-inflammatory influences of royal jelly and melittin and their effectiveness on wound healing

Highlights

  • Royal jelly has antioxidant, anti-inflammatory, anti-tumor, and anti-allergy functions.
  • Melittin as the main component of bee venom has cytotoxic, antibacterial, anticancer, and anti-inflammatory effects.
  • Royal jelly and melittin can play a role in wound healing with different mechanisms.

Keywords

Main Subjects

References

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Central Asian Journal of Medical and Pharmaceutical Sciences Innovation
Volume 3, Issue 2
March and April 2023
Pages 38-47

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