Potential therapeutic effects of herbal drug resveratrol against cancer

Document Type : Review Paper

Author

Department of Plant Production and Genetics, Faculty of Agriculture, Razi University, Kermanshah, Iran

10.22034/CAJMPSI.2022.06.01

Abstract

Cancer is a major global problem that faces many therapeutic challenges. Drug resistance can be an important problem in cancer treatment with chemotherapy. The use of plant-based compounds that have anti-cancer properties has recently been considered in the fight vs. cancer. One of these compounds is the natural substance resveratrol, which has many biological effects on cancer prevention and cancer treatment. This substance exists in more than 70 plant types, including grapes, peanuts, berries, plums, etc. Resveratrol has had a wide range of pharmacological features in recent years. It seems that this drug combination can be involved in various cellular mechanisms. For example, this compound can affect the molecules involved in the oxidative stress pathway and thus have anti-cancer effects. This compound can also affect molecules involved in the apoptosis pathway, affecting tumors. In addition, this compound has anti-angiogenic properties, which is a clear anti-cancer property. However, Resveratrol could be a suitable candidate in the treatment of cancer. In this review, we describe the therapeutic properties of Resveratrol in cancer based on its molecular mechanisms.

Graphical Abstract

Potential therapeutic effects of herbal drug resveratrol against cancer

Highlights

  • Resveratrol could be a good candidate for cancer treatment.
  • Resveratrol may overcome cancer by interfering with antioxidant pathways.
  • Resveratrol can interfere with pathways associated with apoptosis.

Keywords

Main Subjects


1. Anisimova NY, Kiselevsky MV, Sosnov AV, Sadovnikov SV, Stankov IN, Gakh AA. Trans-, cis-, and dihydro-resveratrol: a comparative study. Chem Cent J 2011; 5(1): 1-6.
2. Keylor MH, Matsuura BS, Stephenson CR. Chemistry and biology of resveratrol-derived natural products. Chem Rev 2015; 115(17): 8976-9027.
3. Walle T. Bioavailability of resveratrol. Ann NY Acad Sci 2011; 1215(1): 9-15.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
5. Su D, Cheng Y, Liu M, Liu D, Cui H, Zhang B, Zhou S, Yang T, Mei Q. Comparision of piceid and resveratrol in antioxidation and antiproliferation activities in vitro. PloS One 2013; 8(1): e54505.
6. Salehi B, Mishra AP, Nigam M, Sener B, Kilic M, Sharifi-Rad M, Fokou PV, Martins N, Sharifi-Rad J. Resveratrol: A double-edged sword in health benefits. Biomedicines 2018; 6(3): 91.
7. Park S, Lim J, Kim JR, Cho S. Inhibitory effects of resveratrol on hepatitis B virus X protein-induced hepatocellular carcinoma. J Veter Sci 2017; 18(4): 419-429.
8. Li R, Jia Z, Trush MA. Defining ROS in biology and medicine. React Oxygen Spec 2016; 1(1): 9-21.
9. Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacognosy Rev 2010; 4: 118-126.
10. Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O. Oxidative stress and antioxidant defense. World Allerg Organize J 2012; 5: 9-19.
11. Shahidi F. Antioxidants in food and food antioxidants. Die Nahrung 2000; 44: 158-163.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
12. Zhang LX, Li CX, Kakar MU, Khan MS, Wu PF, Amir RM, Dai DF, Naveed M, Li QY, Saeed M, Shen JQ. Resveratrol (RV): A pharmacological review and call for further research. Biomed Pharmacother 2021; 143: 112164.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
13. Gülçin İ. Antioxidant properties of resveratrol: A structure–activity insight. Innov Food Sci Emerg Technol 2010; 11: 210-218.
14. Mukherjee S, Dudley JI, Das DK. Dose-dependency of resveratrol in providing health benefits. Dose-Response Public Int Hormesis Soc 2010; 8: 478-500.
15. Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget 2018; 9(6): 7204.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
17. Fuggetta MP, Bordignon V, Cottarelli A, Macchi B, Frezza C, Cordiali-Fei P, Ensoli F, Ciafrè S, Marino-Merlo F, Mastino A, Ravagnan G. Downregulation of proinflammatory cytokines in HTLV-1-infected T cells by Resveratrol. J Exp Clin Cancer Res 2016; 35(1): 1-9.
18. Zhang C, Zhao XH, Yang L, Chen XY, Jiang RS, Jin SH, Geng ZY. Resveratrol alleviates heat stress-induced impairment of intestinal morphology, microflora, and barrier integrity in broilers. Poultry Sci 2017; 96(12): 4325-4332.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
19. Zhang H, Chen Y, Chen Y, Ji S, Jia P, Li Y, Wang T. Comparison of the protective effects of resveratrol and pterostilbene against intestinal damage and redox imbalance in weanling piglets. J Anim Sci Biotechnol 2020; 11(1): 1-6.
20. Xian Y, Gao Y, Lv W, Ma X, Hu J, Chi J, Wang W, Wang Y. Resveratrol prevents diabetic nephropathy by reducing chronic inflammation and improving the blood glucose memory effect in non-obese diabetic mice. Naunyn-Schmiedeberg's Arch Pharmacol 2020; 393(10): 2009-2017.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
21. Zou M, Yang W, Niu L, Sun Y, Luo R, Wang Y, Peng X. Polydatin attenuates Mycoplasma gallisepticum (HS strain)-induced inflammation injury via inhibiting the TLR6/MyD88/NF-κB pathway. Microb Pathogen 2020; 149: 104552.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
22. Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, Fong HH, Farnsworth NR, Kinghorn AD, Mehta RG, Moon RC. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 1997; 275(5297): 218-220.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
23. Hou Y, Zhang Y, Mi Y, Wang J, Zhang H, Xu J, Yang Y, Liu J, Ding L, Yang J, Chen G. A Novel Quinolyl‐Substituted Analogue of Resveratrol Inhibits LPS‐Induced Inflammatory Responses in Microglial Cells by Blocking the NF‐κB/MAPK Signaling Pathways. Mole Nutr Food Res 2019; 63(20): 1801380.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
25. Meng T, Xiao D, Muhammed A, Deng J, Chen L, He J. Anti-inflammatory action and mechanisms of resveratrol. Molecules 2021; 26(1): 229.
26. Zhong LM, Zong Y, Sun L, Guo JZ, Zhang W, He Y, Song R, Wang WM, Xiao CJ, Lu D. Resveratrol inhibits inflammatory responses via the mammalian target of rapamycin signaling pathway in cultured LPS-stimulated microglial cells. PloS One 2012; 7(2): e32195.
27. Pinheiro DM, de Oliveira AH, Coutinho LG, Fontes FL, de Medeiros Oliveira RK, Oliveira TT, Faustino AL, da Silva VL, de Melo Campos JT, Lajus TB, de Souza SJ. Resveratrol decreases the expression of genes involved in inflammation through transcriptional regulation. Free Rad Biol Med 2019; 130: 8-22.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
29. Palomera-Ávalos V, Griñán-Ferré C, Izquierdo V, Camins A, Sanfeliu C, Canudas AM, Pallàs M. Resveratrol modulates response against acute inflammatory stimuli in aged mouse brain. Exp Gerontol 2018; 102: 3-11.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed    PubMed Central
33. Cui X, Ruoxi-Chen, Keqing-Zhao, Zhang Q. Overexpression of heme oxygenase-1 in mesenchymal stromal cells: a novel therapeutic approach for allergic rhinitis. Acta Med Mediter 2022; 38(2): 1143-1149.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
35. Shah S, Ahmed MM, Mahmood-ur-Rahman, Chaudhry Z, Aslam A, Nisar N, Abbas G, Khurram H, Mukhtar A, Noureen S, Zulfiqar N. Utilization of Self-Medication, Prescription Medication and Herbal Remedies During Pregnancy in Punjab, Pakistan. Lat Am J Pharm 2021; 40(2): 339-346.
36. Ashrafizadeh M, Taeb S, Haghi-Aminjan H, Afrashi S, Moloudi K, Musa AE, Najafi M, Farhood B. Resveratrol as an enhancer of apoptosis in cancer: A mechanistic review. Anti-Cancer Agents Med Chem 2021; 21(17): 2327-2336.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
37. Teng X, Guo K, Gu Y, Liu J, Yang X, Ma X, Lv W. The therapeutic effect of irbesartan combined with nursing care in the treatment of patients with essential hypertension. Acta Med Mediter 2021; 37(6): 3209-3213.
39. Kania E, Roest G, Vervliet T, Parys JB, Bultynck G. IP3 receptor-mediated calcium signaling and its role in autophagy in cancer. Front Oncol 2017; 7: 140.
40. Danese A, Patergnani S, Bonora M, Wieckowski MR, Previati M, Giorgi C, Pinton P. Calcium regulates cell death in cancer: Roles of the mitochondria and mitochondria-associated membranes (MAMs). Biochim Biophys Acta Bioenerg 2017; 1858(8): 615-627.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
42. Chen W, Yu X, Wang N, Jing J, Ma X, Li R. The therapeutic effect of deep brain stimulation at medial globus pallidus and subthalamic nucleus on treating parkinson disease. Acta Med Mediter 2021; 37(5): 2293-2300.
43. Buhrmann C, Shayan P, Popper B, Goel A, Shakibaei M. Sirt1 Is Required for Resveratrol-Mediated Chemopreventive Effects in Colorectal Cancer Cells. Nutrients 2016; 8: 145.
44. Chen Y, Tseng SH. Review. Pro and anti-angiogenesis effects of resveratrol. In vivo (Athens, Greece) 2007; 21: 365-370.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
45. Bråkenhielm E, Cao R, Cao Y. Suppression of angiogenesis, tumor growth, and wound healing by resveratrol, a natural compound in red wine and grapes. FASEB J Offic Public Feder Am Soc Exp Biol 2001; 15: 1798-1800.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
47. Fang Y, Lou C, Ding Y, Liu L. Resveratrol plays a protective role in the liver by regulating apoptosis and SIRTI/HMGB1 signaling pathways. Acta Med Mediter 2021; 37(3): 1665-1669.
48. Guo R, Li W, Liu B, Li S, Zhang B, Xu Y. Resveratrol protects vascular smooth muscle cells against high glucose-induced oxidative stress and cell proliferation in vitro. Med Sci Monit Basic Res 2014; 20: 82-92.
49. Sato M, Pei RJ, Yuri T, Danbara N, Nakane Y, Tsubura A. Prepubertal resveratrol exposure accelerates N-methyl-N-nitrosourea-induced mammary carcinoma in female Sprague-Dawley rats. Cancer Lett 2003; 202: 137-45.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
50. Garvin S, Ollinger K, Dabrosin C. Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo. Cancer Lett 2006; 231: 113-122.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
51. Bove K, Lincoln DW, Tsan MF. Effect of resveratrol on growth of 4T1 breast cancer cells in vitro and in vivo. Biochem Biophys Res Commun 2002; 291: 1001-1005.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
52. Song J, Leng B, He X, Li B, Wang R. The mechanism of hela cells as an anticancer drug based on hap nanoparticles. Acta Med Mediter 2022; 38(1): 569-577.
53. Provinciali M, Re F, Donnini A, Orlando F, Bartozzi B, Di Stasio G, Smorlesi A. Effect of resveratrol on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Int J Cancer 2005; 115: 36-45.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
55. Cui X, Jin Y, Hofseth AB, Pena E, Habiger J, Chumanevich A, Poudyal D, Nagarkatti M, Nagarkatti PS, Singh UP, Hofseth LJ. Resveratrol suppresses colitis and colon cancer associated with colitis. Cancer Preven Res 2010; 3: 549-559.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
59. Saud SM, Li W, Morris NL, Matter MS, Colburn NH, Kim YS, Young MR. Resveratrol prevents tumorigenesis in mouse model of Kras activated sporadic colorectal cancer by suppressing oncogenic Kras expression. Carcinogenesis 2014; 35: 2778-2786.
60. Harper CE, Patel BB, Wang J, Arabshahi A, Eltoum IA, Lamartiniere CA. Resveratrol suppresses prostate cancer progression in transgenic mice. Carcinogenesis 2007; 28: 1946-1953.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
61. Seeni A, Takahashi S, Takeshita K, Tang M, Sugiura S, Sato SY, Shirai T. Suppression of prostate cancer growth by resveratrol in the transgenic rat for adenocarcinoma of prostate (TRAP) model. Asian Pacific J Cancer Prevent 2008; 9: 7-14.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
62. Wang TT, Hudson TS, Wang TC, Remsberg CM, Davies NM, Takahashi Y, Kim YS, Seifried H, Vinyard BT, Perkins SN, Hursting SD. Differential effects of resveratrol on androgen-responsive LNCaP human prostate cancer cells in vitro and in vivo. Carcinogenesis 2008; 29: 2001-2010.
63. Brizuela L, Dayon A, Doumerc N, Ader I, Golzio M, Izard JC, Hara Y, Malavaud B, Cuvillier AO. The sphingosine kinase-1 survival pathway is a molecular target for the tumor-suppressive tea and wine polyphenols in prostate cancer. FASEB J Offic Publicat Feder Am Soc Exp Biol 2010; 24: 3882-3894.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
64. Ganapathy S, Chen Q, Singh KP, Shankar S, Srivastava RK. Resveratrol enhances antitumor activity of TRAIL in prostate cancer xenografts through activation of FOXO transcription factor. PloS One 2010; 5: e15627.
65. Li K, Dias SJ, Rimando AM, Dhar S, Mizuno CS, Penman AD, Lewin JR, Levenson AS. Pterostilbene acts through metastasis-associated protein 1 to inhibit tumor growth, progression and metastasis in prostate cancer. PloS One 2013; 8: e57542.
66. Revel A, Raanani H, Younglai E, Xu J, Rogers I, Han R, Savouret JF, Casper RF. Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects lung from DNA damage and apoptosis caused by benzo [a] pyrene. J Appl Toxicol Int J 2003; 23(4): 255-261.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
67. Yu YH, Chen HA, Chen PS, Cheng YJ, Hsu WH, Chang YW, Chen YH, Jan Y, Hsiao M, Chang TY, Liu YH. MiR-520h-mediated FOXC2 regulation is critical for inhibition of lung cancer progression by resveratrol. Oncogene 2013; 32: 431-443.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
69. Busquets S, Ametller E, Fuster G, Olivan M, Raab V, Argilés JM, López-Soriano FJ. Resveratrol, a natural diphenol, reduces metastatic growth in an experimental cancer model. Cancer Lett 2007; 245: 144-148.
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed   
CrossRef    Google Scholar    full-text PDF    Mendeley    PubMed